摘要
为观察依那普利治疗神经心源性晕厥的疗效。对４８例倾斜试验重复性良好的阳性神经心源性晕厥患者分别口服安慰剂及依那普利（５ｍｇ，２／ｄ）１周后复查倾斜试验。结果发现安慰剂组２４例神经心源性晕厥患者仅８例倾斜试验检查转阴，转阴率３３．３％；依那普利组２４例，除３例因干咳副作用退出试验外，余２１例神经心源性晕厥均转阴，Ｐ＜０．００１。平均随访１３．４±２．１个月，安慰剂组２４例中有１３例发作神经心源性晕厥，发作率５４．２％，而依那普利组２１例无１例再发。
To investigate the effects of oral enalapril on neurally mediated syncope, 48 patients with unexplained syncope and positive response to head-up tilt table test were repeated tilt table test after administering enalapril or placebo for one week. During the repeat tilt table test , response was negative in 8 of 24 cases (33.3%) after administration of placebo, none of 24 cases was positive after enalapril treatment,except three cases discontinued enalapril because of dry cough. Enalapril or placebo was administered orally for an average of 13.4±2.1 months, 13 of 24 patients reoccured syncope in placebo-treated group,but none of patients in enalapril-treated group reoccured presyncope or syncope. Administering angiotensin converting enzyme inhibitor orally may be effective for neurally mediated syncope in patients.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
1998年第3期137-140,共4页
The Chinese Journal of Clinical Pharmacology
