糖尿病人乙酰化代谢表型研究

ACETYLATOR PHENOTYPING IN CHINESE POPULATION WITH DIABETES MELLITUS

以咖啡因为代谢探针，研究汉族人群糖尿病（ＤＭ）及慢性并发症与Ｎ－乙酰化表型间的相关性。Ⅰ、Ⅱ型ＤＭ组快乙酰化代谢表型的频率分别为９２．３％和８７．８％，高于健康人群的７３．４％，比值比（ＯＲ）分别为４．３５与２．６１。乙酰化代谢表型分布有或无慢性并发症无显著差异。快乙酰化代谢表型患者有神经病变或心脏病变组ＡＦＭＵ／１Ｘ均值显著低于无相应病变组，与年龄、发病年龄、病程呈显著负相关，与血果糖胺水平呈显著正相关。快乙酰代谢表型可能为汉族人群ＤＭ的遗传易感因素。患者年龄、发病年龄。

To examine the relationship between diabetes mellitus(DM,type Ⅰ and Ⅱ)or its chronic complications and acetylator phenotypes in Chinese population and clarify whether the acetylator status could be a genetic susceptible factor for DM or its chronic complications. A total of 108 Chinese diabetics were included. Significant differences in the proportion of fast or slow acetylators were observed between typeⅠ(92.3% or 7.7%) or type Ⅱ (87.8% or 12.2%) DM and control (73.4% or 26.6%). The odds ratio (OR) was 4.35 and 2.61 for fast acetylators or 0.23 and 0.38 for slow ones respectively. The mean AFMU/1X was lower in fast acetylators with neuropathy or cardiopathy than in those without them. Linear correlation of acetylation rate upon age, onset -age,clinical course and plasma fructosamine level in fast acetylators was observed but not in slow acetylators. The acetylate status may be one of the genetic factors that influence the susceptibility to diabetic neuropathy or diabetic cardiopathy, and change with age, onset-age,clinical course or blood fructosamine level in some way.