有机锗对铅所致小鼠学习记忆障碍的拮抗作用

Effect of germanium on learning and memory disturbance caused by lead in mice

用避暗法和水迷宫法研究了锗对铅所致的小鼠学习记忆障碍的影响。ＩＣＲ系小鼠隔日腹腔注射羧乙基锗倍半氧化物（Ｇｅ－１３２，２５ｍｇ／ｋｇ）和／或醋酸铅（１５ｍｇ／ｋｇ）２８天。结果表明暴露于铅２０天后小鼠学习记忆能力受障碍，同时给予Ｇｅ－１３２能明显地拮抗铅的这种毒作用。提示。

By using step through test and water maze test the effects of germanium on ICR mouse learning and memory disturbance caused by lead were studied by administering i.p. carboxyethylgermanium sesquioxide i.p.(Ge-132,25 mg/kg)and/or lead acetate(PbAc2,15 mg/kg)for 28 days,one time every two days.The results showed that after exposure to 20 days the learning and memory disturbance caused by the injection of PbAc2 was antagonized by Ge-132 significantly(P<0.01).This suggested that Ge-132 might play a protective role in neurobehavioral function damage induced by lead.