干扰素诱导蛋白10对结核性胸膜炎的诊断价值

The significance of detecting interferon-inducible protein 10 in the pleural effusion for diagnosis of tuberculous pleurisy

目的:研究胸水中干扰素诱导蛋白10(interferon-inducible protein 10,IP-10)水平对结核性胸膜炎的诊断价值。方法:用ELISA检测43例结核性胸膜炎和33例恶性胸腔积液患者胸水中IP-10水平;绘制受试者工作特征曲线(receiver operating characteristic curve,ROC曲线)确定其诊断结核性胸膜炎的临界值,并评价其敏感性、特异性和诊断效能。结果:结核性胸膜炎组胸水中IP-10含量为(1 095.67±556.29)pg/ml,显著高于恶性胸腔积液组(121.39±61.21)pg/ml,P<0.01。IP-10诊断结核性胸膜炎的临界值为194.5 pg/ml,敏感性和特异性分别为83.7%和97.0%;IP-10的诊断效能与γ-干扰素(IFN-γ)相近。结论:胸水中IP-10水平测定有助于结核性胸膜炎的诊断。

Objective：To evaluate the significance of interferon-inducible protein 10 （IP-10） level in the pleural effusion for the diagnosis of tuberculous pleurisy. Methods： Enzyme-linked immunosorbent assay （ELISA） was adopted to detect the level of IP-10 in 43 patients with tuberculous pleurisy and 33 patients with pleural effusion associated with malignant tumor. The receiver operating characteristic （ROC） curves were used to determine the cut-off value and assess the sensitivity,specificity and diagnostic efficiency. Results：The concentration of IP-10 was significantly higher in tuberculous pleurisy （1 095.67 - 556.29 pg/ml） than in malignant pleurisy （121.39±61.21 pg/nd）, （P 〈 0.01）. When 194.5 pg/ml was used as cut-off value,the sensitivity and specificity for IP-10 in diagnosis of tuberculous pleurisy were 83.7% and 97.0%,respectively. And the diagnostic efficiency of IP-10 was similar to that of IFN-γ. Conclusion：Detection of IP-10 in the pleural effusion is helpful in the diagnosis of tuberculous pleurisy.