奥曲肽联合多巴胺治疗肝肾综合征的临床研究

Clinical Research on Hepatorenal Syndrome Treated by Octreotide Combined with Dopamine

目的:观察奥曲肽联合多巴胺治疗肝肾综合征的临床疗效。方法:将38例肝肾综合征患者随机分为两组。治疗组20例应用奥曲肽联合多巴胺治疗,同时给予白蛋白和速尿等内科综合对症支持治疗;对照组18例常规给予白蛋白和速尿等对症支持治疗。两组治疗前后比较临床治愈好转率,并观察Cr、BUN、Na+、K+定量检测指标的变化。结果:治疗组治疗后总有效率为65.0%(13/20),对照组治疗后总有效率为22.2%(4/18),两组治疗有效率比较差异有统计学意义(P<0.05)。同时治疗组肾功能明显好转,电解质紊乱纠正,检测Cr、BUN、Na+两组比较差异有统计学意义(P<0.05)。结论:奥曲肽联合多巴胺治疗肝肾综合征有较好疗效。

Objective： To observe the octreotide combined with dopamine in the treatment of hepatorenal syndrome. Methods： 38 cases of patients with hepatorenal syndrome were randomly divided into two groups. In the treatment group 20 cases were treated by octreotide combined with dopamine, support therapy were given with aibumin and furosemide at the same time. 18 cases in the control group were given with aibumin and furosemide. Compared the clinical cure rate of the two group before and after treatment . To observe Cr, BUN, Na, K quantitative detection of the changes in indicators. Results： After treatment, the total effective rate was 65.0 % （13/20）, the control group was 22.2 % （4/18）, there was significant differences between the two groups. At the same time, the treatment group siginificantly improved renal function, electrolyte imbalance corrected, detected Cr, BUN, Na between the two groups was statistically significant （P 〈 0.05）. Conclusion： The oc- treotide combined with dopamine in the treatment of hepatorenal syndrome was efficacy.