新型与传统抗精神病药物对心电图的影响

The New Types of Antipsychotics and Traditional Antipsychotics' Influence on ECG

目的:探讨精神分裂症患者应用新型(非典型)抗精神病药物与传统(典型)抗精神病药物后心电图变化的差异情况。方法:600例精神分裂症患者分别使用阿立哌唑、利培酮、氯氮平、氯丙嗪治疗,分别于第1、2、3个月复查心电图。结果:使用新型(非典型)抗精神病药物3个月后患者心电图改变显著低于使用传统(典型)抗精神病药物患者(P<0.05);心电图改变与性别、年龄无关,与使用药物剂量有关。结论:新型抗精神病药物导致心电图异常率较典型抗精神病药物低,临床使用具有较高的安全性。

Objective： Purpose this paper is to discuss the difference between changes of ECG of the mad- men who use the new types of antipsychotics and those of the ones who use traditional antipsychotics. Method： 600 madmen take Aripiprazole, Risperidone, Clozapine, Chlorpromazine, respectively and check the ECG in the first, the second and the third month. Results： the changes of ECG of the patients who have taken new types antipsychotics of for three months is significantly lower than those of the ones who have taken traditional antipsychotics; the changes of ECG related to dose of medicine, but not to gender or age. Conclusion： the rate of ECG anomaly caused by the new types of antipsychotics is lower than that caused by traditional ones, thus the new types of antipsychotics are safer for clinical practice.