慢性砷中毒患者皮肤过度角化的切除和病理改变

Excision and pathological changes of skin hyperkereratosis caused by chronic arsenic poisoning

对１０２例皮损病人手术局限切除皮肤过度角化痛点、溃疡点，不但病灶清除，疼痛消失，局部功能恢复，而且预防恶变。其治愈率达８７．２％，总有效率达９６％。指出尽早、彻底地切除病灶组织是保证手术成功的关键。４４例手术组织病理显示：皮肤角化层增厚，棘层肥厚和表皮乳头样增生为主要病理变化，表皮下纤维增生次之，纤维间质粘液变性，炎症细胞浸润，组织萎缩均有存在。核异质现象和癌细胞的检出率各占６．８１％和４．５４％。

One hundred and two cases of patients with skin lesion cured by surgery operation showd:after local focusexcision of hyperkerations,the sore spots of skin,wlcer spots,and the illfocus are cleaned.Pain disappears,functions recover,and the deterioration is prevented.The curable rate is 87.2%.The effectiue rate is 96%.Authors pointed out that clearing early excising completely is the key to assure the operation to succeed.Fourty four cases of pathologic examination showed that the chief pathologic changes of skin are thicken of keratinous layer,hypertrophy of acanthaceous layer and papillomalike hyperplasis of epidermis.Fibre byperplasis of subepidermis is next.Mucus degeneration of fibrous inter membrane,infiltration of inflammatory cell,and tissue atrophy are existent.proportion of hetorochromatia and sguamus carcinoma is 6.81% and 4.54%,respectively