儿童原发性肾病综合征糖皮质激素耐药机制研究进展

Research progress on glucocorticoid resistance mechanism in primary nephrotic syndrome of childhood

糖皮质激素作为原发性肾病综合征最重要和首选的治疗药物,在临床上使用已逾半个多世纪,尽管大多数儿童原发性肾病综合征对糖皮质激素敏感而预后较好,但仍有约10%～20%表现为激素耐药性肾病综合征,激素耐药机制已成为肾脏疾病研究的热点课题。该文就其近年来有关国内外儿童原发性肾病综合征糖皮质激素耐药机制研究进展作一综述。

Glucocorticoids （GCs） are among the most important and preferred therapeutic drugs for the clinical treatment of primary nephrotic syndrome from more than half a century. There is a sensitivity and prognostic significance of the glucocorticoid treatment in children with nephrotic syndrome, but 10%-20% patients are steroid-resistant nephrotic syndrome. Mechanisms of hormone resistance have become focused in renal disease research. This pa- per summarizes recent domestic and foreign research progress on glucocorticoid resistance mechanism in primary nephmtic syndrome of childhood.