有关Alzheimer病的生化指标研究的进展

The Putative Biochemical and Metabolic Markers in Alzheimer′s Disease

随着人口老化现象的日益严重，Ａｌｚｈｅｉｍｅｒ病（ＡＤ）越来越受到人们的重视。大量的研究结果表明，ＡＤ的主要病理改变是脑内细胞外老年斑（ＳＰ）和细胞内神经原纤维缠结（ＮＦＴ）。神经生化和分子生物学的研究揭示出二者的形成与β淀粉样蛋白和ｔａｕ蛋白的异...

Alzheimer′s disease (AD) is one of the neurodegenerative disorders associated with progressive dementia The neuropathological features usually showed the presence of intracellular neurofibrillary tangles and extracellular neuritic plaues within the brain Neurochemical and molecular neurobiological studies demonstrated that the formations of the pathological changes might be related to some disturbances of amyloid β proteins, microtuble associated protein tau as well as expression of the mutated genes, though the early diagnosis of AD seems still difficult to date This paper summarized here some new advances on putative markers, such as β amyliod protein, tau protein, apolipoprotein E genotypes, protease activities, neurotransmitters and their metabolites, lipids and other biochemical markers in diagnosis of AD