塞来昔布对苯并芘致大鼠胃肿瘤的影响研究

Effect of Celecoxib on Stomach Tumor Induced by Benzo-pyrene in Rats

目的:探讨选择性环氧合酶-2抑制剂塞来昔布对大鼠胃肿瘤发生的预防作用。方法:取SD大鼠100只,除20只为正常对照组外,其余80只大鼠以苯并芘灌胃造模,4周后将大鼠随机均分成模型对照组和塞来昔布大、中、小剂量(15、10、5mg·kg-1)组;正常对照组及模型对照组喂养普通饲料,塞来昔布组喂养相应的含药饲料,分别于10周和21周时观察各组大鼠胃肿瘤发生率、肿瘤发生数量和肿瘤体积。结果:与模型对照组比较,塞来昔布中、大剂量组肿瘤发生率和发生数量较低(P<0.01或P<0.05),肿瘤体积无明显差异。结论:塞来昔布具有抑制大鼠胃肿瘤发生的作用。

OBJECTIVE： To investigate the preventive effect of celecoxib, a selective cyclooxygenase （COX） - 2 inhibitor, on stomach tumor in rats. METHODS： A total of 100 SD rats were randomly divided into 2 groups： of which, 20 served as normal control, another 80 were intragastrically administrated with benzo pyrene to induce stomach tumor. Four weeks later, the model rats were randomly divided into 4 groups： model control group and celecoxib high, medium and low dosage（ 15,10,5 mg· kg^-1） groups. The normal control group and model control group were fed with common feedstuff, while celecoxib groups with corresponding drug - containing feedstuff. The incidence, number and size of stomach tumors were recorded at 10 and 21 weeks, respectively. RESULTS： As compared with the model control group, the incidence and number of stomach tumors in celecoxib groups （medium and high dosage） were lower （P 〈 0.01 or P 〈 0.05）, however, the difference in tumor size was not significant. CONCLUSION： Celecoxib has inhibition on the incidence of stomach tumor in rats.