马钱子的毒性研究进展

Progressive studies on toxity of Strychons nuxvomica

马钱子有较明显的药效,在临床及民间多有应用,但因马钱子治疗剂量与中毒剂量较接近,其临床应用的毒副反应报道也多,限制了马钱子的广泛使用。马钱子在治疗各种疾病中疗效肯定,是具有较大开发潜力的中药。文章回顾和分析了近年来研究有毒中药马钱子的文献,总结并归纳马钱子在化学成分、毒理学、药代动力学、减毒增效方面的研究进展,为今后深入进行中药毒性,特别是马钱子的毒性研究提供相关的依据,并针对马钱子减毒增效的机制为马钱子的临床应用提供了合理性的建议。

Strychons nuxvomica is widely used by clinic and individual owing to its officinal value. Since toxic dose and therapeutic dose are very close, the poisoning cases are reported frequently. In this review, based on the recent available papers published in the PubMed and CNKI about Strychons nuxvomica, a traditional Chinese herbal medicine, we present the major current approaches in the field of composition, toxicology, pharmacokinetics, decreasing toxicity and increasing efficacy, in order to guide the use of S. nuxvomica in the clinic.