高血压病与高胰岛素血症关系的初步探讨

Preliminary study on hyperinsulinemia in patients with essential hypertension.

为研究高血压病（ＥＨ）病人的高胰岛素血症及高血压有关的相关因素，对ＥＨ３３例采用氧化酶法检测糖耐量，放射免疫法测胰岛素（ＩＳ）和Ｃ肽（ＣＰ）释放试验。结果：ＥＨ组的服糖后２ｈ、３ｈ血糖（ＢＧ）和３ｈ的ＩＳ和ＣＰ明显高于ＣＯ组（Ｐ＜０．０５）。舒张压（ＤＰ）和平均压（ＭＡＰ）均与服糖后２ｈＢＧ显著正相关。多因素逐步回归分析提示ＳＰ、ＤＰ和ＭＡＰ均与服糖后２ｈＢＧ密切相关。认为ＥＨ病入存在胰岛素抵抗和高胰岛素血症。

The aim of the study was to investigate the hyperinsulinemia in patients with essential hypertension (EH) and the related factors to hypertension Blood glucose (BG), insulin (IS) and C-peptide (CP) levels during oral glucose toleranec test (OGTT) were measured in 33 patients with EH and 23 control (CO) subjects The results showed that BG at 2 and 3 hour, IS and CP at 3 hour postload during OGTT significantly increased in EH patients compared with CO group (P<0 05); that the diastolic blood pressure (DP) and mean artery pressure (MAP) correlated positively with BG at 2 hour postload during OGTT Multiple regression analysis demonstrated that, SP、DP and MAP had a close relationship with BG at 2 hour postload during OGTT The study suggests that:There are IS resistance and hyperinsulinemia in EH patients, and that hypertension has a close relationship with BG at 2 hour postload during OGTT