幽门螺杆菌根除失败原因及补救策略分析

Analysis of Common Reasons for Unsuccessful Eradication of Helicobacter Pylori and Rescue Therapy Strategy

幽门螺杆菌(Hp)与胃炎、消化性溃疡、胃黏膜相关淋巴组织淋巴瘤及胃癌关系密切。随着根除Hp治疗在临床的普遍开展,Hp根除率逐渐下降,其主要原因是日益突出的抗生素耐药及患者对药物依从性差。对根除治疗失败者进行补救治疗已成为Hp治疗研究领域的新热点。由于各地的Hp耐药率及感染者个体情况存在很大差异,目前尚未形成统一规范的补救策略,遵循个体化的补救策略已逐渐被大家所接受。

Helicobacter pylori has closely related with chronic gastritis, peptic ulcer disease, MALT and gastric cancer. With the widespread development of Hp eradication therapy, the eradicating rate of Hp become lower and lower gradually. The main reason is increasing antibiotic resistance and the poor drug compliances of the patients. Rescue therapy for therapy failure has become a new hot spot in Helicobacter pylori research area. Due to the different antibiotic resistance rate and individual patient characteristic, there are no standard rescue schedule at present, but it has been accepted that the rescue strategy should be applied based on individuation principle.