ANCA相关性小血管炎并肾脏损害的临床分析

Clinical Analysis Of ANCA Associated Small Vessel Glomerulonephritis

目的探讨抗中性粒细胞胞浆抗体(ANCA)相关性小血管炎并肾炎的临床诊治方法。方法对20例确诊为ANCA相关性小血管炎并肾炎的患者临床资料进行总结分析。结果ANCA相关性小血管炎并肾炎临床表现多样,全身各系统均可受累,以肺、肾受累为主。一旦肾脏受累,表现为RPGN,经皮质激素,细胞毒药物治疗,部分患者肾功能得到改善,脱离透析治疗。结论ANCA相关性小血管炎并肾炎临床表现多样,早期诊断,早期适当治疗可改善患者预后。

Objective To study the clinical significant, pathological feature, diagnosis and treatment ofAntineutrophil cytoplasimic antibody（ANCA） associated small vessel vasculitis complicating glomerulonephritis.Methods To summarize and analysise the clinical documents of the defined patients with ANCA associated small vessel vasculitis complicating glomerulonephritis. Results The disease has varied clinical significant, and involves every systemof the body, especially lung and kidney. Once it involves the kindney, the clinical significant is PPGN. Through the treatment ofcorticosteroids, cytotoxic drug and others, the renal function of some patients has been improved.Conclusion The clinical siganificant of ANCA asocciated small vessel vasculitis copmliating glomerulonephritis is lack of the specificity. Eearly diagnosis and proper teaetment may improve the prognosis of the patient.