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CD4^+CD25^+调节性T细胞及其分子标记物与支气管哮喘 被引量：2

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摘要 CD4+CD25+调节性T细胞是一类以免疫抑制和免疫无能为特征的淋巴细胞群,FOXP3是CD4+CD25+调节性T细胞一个特征性的分子标志物,并且对CD4+CD25+调节性T细胞的发育、外周表达和功能维持有着关键性的作用。近年来,多项研究显示CD4+CD25+调节性T细胞参与并影响了支气管哮喘的发生、发展过程,对调节性T细胞或其相关基因的干预也许会成为支气管哮喘治疗的新方向。
作者 马祥 毛辉 梁宗安
机构地区 四川大学华西医院呼吸内科
出处 《中华哮喘杂志（电子版）》 CAS 2009年第4期49-52,共4页 Chinese Journal of Asthma(Electronic Version)
关键词 CD4+CD25+调节性T细胞 FOXP3 哮喘
分类号 R392.4 [医药卫生—免疫学] R562.25 [医药卫生—呼吸系统]
  • 相关文献

参考文献3

  • 1薛克营,周咏明,熊盛道,熊维宁,唐滔.Analysis of CD4^+CD25^+ Regulatory T Cells and Foxp3 mRNA in the Peripheral Blood of Patients with Asthma[J].Journal of Huazhong University of Science and Technology(Medical Sciences),2007,27(1):31-33. 被引量：15
  • 2Keying Xue,Yongming Zhou,Shengdao Xiong,Weining Xiong,Tao Tang. Analysis of CD4+CD25+ regulatory T cells and Foxp3 mRNA in the peripheral blood of patients with asthma[J] 2007,Journal of Huazhong University of Science and Technology(1):31～33
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二级参考文献10

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共引文献14

同被引文献20

  • 1谭楠,吴昌归.哮喘患者外周血CD_4^+CD_(25)^+调节性T细胞的表达及临床意义[J].陕西医学杂志,2007,36(1):102-104. 被引量：6
  • 2郭胤仕,许以平.调节性T细胞及其与支气管哮喘发病的关系[J].国际呼吸杂志,2007,27(7):502-505. 被引量：2
  • 3Chen X,Murakami T,Oppenheim JJ,et al. Differential response of murine CD4+CD25 + and CD4+CD25 + T cells to dexamethasone-induced cell death[J]. Eur J Immuno1,2004,34 (3) : 859-869.
  • 4Kearley J,Barker JE,Robinson DS,et al. Resolution of airway inflam- mation and hyperreactivity after in vivo transfer of CD4+CD25+ regula tory T cells is interleukin 10 dependent[J]. J Exp Med ,2005,202( 11 ): 1539-1547.
  • 5Lewkowich IP, Herman NS,Schleifer KW,et al. CD4+CD25' T cells pro- tect against experimentally induced asthma and alter pulmonary den- dritic cell phenotype and function[J]. J Exp Med, 2005,202 ( 11 ) : 1549- 1561.
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  • 7李营营,冯学斌.CD4^+CD25^+调节性T细胞在支气管哮喘中的研究进展[J].国际内科学杂志,2007,34(9):545-548. 被引量：6
  • 8Pietruczuk M,Eusebio M,Kraszula L. Phenotypic characterization of ex vivo CD4+CD25highCD127low immune regulatory T cells in allergic asthma:pathogenesis relevance of their FoxP3,GITR,CTLA-4 and FAS expressions[J].{H}Journal of Biological Regulators and Homeost Agents,2012,(04):627-639.
  • 9Holgate ST. Innate and adaptive immune responses in asthma[J].{H}Nature Medicine,2012,(05):673-683.
  • 10Maazi H,Shirinbak S,Willart M. Contribution of regulatory T cells to alleviation of experimental allergic asthma after specific immunotherapy[J].{H}Clinical and Experimental Allergy,2012,(10):1519-1528.

引证文献2

二级引证文献10

中华哮喘杂志（电子版）
2009年 第4期

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