事件相关电位在轻度认知功能障碍诊断中的意义

The value of event-related potentials in the mild cognitive impairment(MCI)

目的探讨轻度认知功能障碍和阿尓茨篋〉氖录喙氐缥?ERP:N100、P300)变化。方法根据Peterson制订的MCI诊断标准,筛选出21例MCI患者(MCI组),22例正常对照者(NC组)以及20例阿尓茨篋?AD)组患者,分别用英国OXFORD脑电生理仪记录事件相关电位(ERP:N100,P300)和视觉诱发电位(VEP)情况。结果(1)AD组MMSE评分(16.52±2.17分)及MCI组(24.33±1.34分)低于正常对照组[(26.57±1.43)分,P<0.01]。(2)AD组与MCI组靶波幅P3和非靶波幅P2均见降低,与NC组比较也有显著性差异(P<0.05、P<0.01)。(3)N100潜伏期、波幅变化不是很大(P>0.05)。(4)AD组P300靶刺激中的P2、P3波潜伏期与MMSE分值呈负相关(P<0.05、P<0.01)。结论AD和MCI患者的P300有多项指标异常对于临床诊断AD和MCI患者有一定价值。事件相关电位与认知功能存在明显相关性,提示事件相关电位可以客观反映AD和MCI患者的认知功能障碍。

Objective To examine Event-related potentials in patients with Alzheimer disease （AD） and mild cognitive impairment （MCI）. Methods According to the criteria of MCI made by Peterson,21 subjects with MCI were diagnosed. 21 patients with MCI,20 patients with AD and 22 normal controls （NC） were recruited. The Event-related potentials （N100 ,P300）and visual evoked potential（VEP） of the subjects were recorded and analysed. Results （1）The AD patients and MCI patients had lower MMSE score than the NCs （P 〈 0.01 ）. （2） Compared with NC group, MCI and AD patients showed decreased P3 amplitude from target and P2 amplitude from nontarget （ P 〈 0.05 ,P 〈 0.01 ）. （ 3 ） The peak latencies and amplitude of N100 had no significant changes （ P 〉 0.05 ）. （4） The delayed P2 and P3 latencies were negatively correlated to MMSE score （P 〈 0.05, 〈 0.01 ）. Conclusion There is significant relationship between P300 and the cognition function, registering that P300 is a more sensitive objective method than others when evaluating the cognition functions. P300 can serve as a physiological index in the accessory diagnosis of the cognitive disorder in MCI and AD.