2Messer A, Strominger NL, Mazurkiewicz JE. Histopathology of the late-onset motor neuron degeneration (Mnd) mutant in the mouse. J Neurogent, 1987,4 : 201-213.
3Faust JR, Rodman JS, Daniel PF,et al. Two related proteolipids and dolichollinked oligosaccharides accumulate in motor neuron degeneration mice (mnd/mnd), a model for neuronal ceroid lipofuscinosis. J Biol Chem, 1994 ,269 : 10150-10155.
4Mitsumoto H, Bradley WG. Murine motor neuron disease (the wobbler mouse) : degeneration and regeneration of the tower motor neuron. Brain, 1982,105 : 811-834.
5Blondet B, Hantaz-Ambroise D, Ait-Ikhlef A, et al. Astroeytosis in wobbler mouse spinal cord involves a population of astrocytes which is glutamine synthetase-negative. Neurosci Lett, 1995,183 : 179-182.
6Chambers DM, Peters J, Abbott CM. The lethal mutation of the mouse wasted ( wst ) is a deletion that abolishes expression of a tissue-specific isoform of translation elongation factor 1alpha, encoded by the Eefla 2 gene. Proc Natl Acad Sci USA, 1998 ,95: 4463 -4468.
7Lutsep HL, Rodriguez M. Ultrastructural, morphometricand, and immumocyotochemical study of anterior horn cells in mice with " wasted" mutation. J Neuropathol Exp Neurol , 1989,48:519-533.
8Schmalbruch H, Jensen HJ, Bjaerg M, et al. A new mouse mutant with progressive motor neuronopathy. J Neuropahol Exp Neurol, 1991,50 : 192-204.
9Bruniahi AL, Poirier C, Schmalbruch H,et al. The mouse mutation progressive motor neuronopathy (pmn) maps to chromosome 13. Genomics, 1995,29 : 131-135.
1Rothstein JD,Jin L,Dykes-Hoberg M,et al.Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity.Proc Natl Acad Sci USA,1993,90:6591-6595.
2Rothstein JD,Bristol LA,Hosler B,et al.Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons.Proc Natl Acad Sci USA,1994,91:4155-4159.
3Annis CM,Vaughn JE.Differential vulnerability of autonomic and somatic motor neurons to n-methyl-d-aspartate-induced exitotoxicity.Neuroscience,1998,83:239-249.
4Brenner C,Kroemer G.Apoptosis.Mitochondria--the death signal integrators.Science,2000,289:1150-1151.
5Green DR,Kroemer G.The pathophysiology of mitochondrial cell death.Science,2004,305:626-629.
6Chung MJ,Suh YL.Ultrastructural changes of mitochondria in the skeletal muscle of patients with amyotrophic lateral sclerosis.Ultrastruct Pathol,2002,26:3-7.
7Shibata N,Nagai R,Uchida K,et al.Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients.Brain Res,2001,917:97-104.
8Borthwick GM,Johnson MA,Ince PG,et al.Mitochondrial enzyme activity in amyotrophic lateral sclerosis:implication for the role of mitochondria in neuronal cell death.Ann Neurol,1999,46:787-790.
10Kaal EC,Vlug AS,Versleijen MW,et al.Chronic mitochondrial inhibition induces selective motoneuron death in vitro:a new model for amyotrophic lateral sclerosis.J Neurochem,2000,74:1158-1165.
