阿仑膦酸钠治疗糖皮质激素性骨质疏松症的临床观察

Effect of alendronate on glucocorticoid-induced osteoporosis

目的:观察阿仑膦酸钠治疗糖皮质激素性骨质疏松症(GIO)的近期疗效。方法:以35例糖皮质激素性骨质疏松症患者为观察对象,每日服用阿仑膦酸钠10mg,治疗6个月,治疗前后采用双能X线骨密度仪测定骨密度。结果:35例患者治疗后腰椎、股骨颈及大转子部位骨密度较治疗前增加(P<0.05),尿钙与尿肌酐比值降低(P<0.05)。副反应轻微。结论:阿仑膦酸钠是治疗糖皮质激素性骨质疏松症的安全有效的药物。

Objective To determine the effect of alendronate on glucocorticoid-induced osteoporosis（GIO）.Methods Thirty-five GIO patients were enrolled.Ten milligrams alendronate were prescribed daily for 6 months.Bone mineral density（BMD） was measured by dual-energy X-ray absorptiometer（DEXA） after and before the treatment.Results BMD at lumbar,neck and trochanter sites of the 35 patients after the treatment was significantly increased compared with those before the treatment（P〈0.05）.Urine Ca/Cr level was decreased（P〈0.05）.There was no severe side effect.Conclusion Alendronate is effective and well tolerated for GIO.