功率谱熵对大鼠痫性发作预报的评估意义

Effect of power spectral entropy on the prediction of seizure in epileptic rats

目的:研究功率谱熵在青霉素致痫大鼠脑电检测中的应用,探索运用功率谱熵进行痫性发作预报的可行性。方法:SD大鼠18只随机分为3组,分别为正常组、对照组、致痫组,致痫组采用青霉素在大鼠海马微注射制备急性痫性发作模型(注射点为右侧海马),用深部电极连续记录大鼠脑电信号,运用功率谱熵对痫性发作大鼠发作全过程的脑电信号进行分析,并与正常组及注射生理盐水对照组进行对比分析。结果:在青霉素致痫大鼠的整个痫性发作过程中,功率谱熵在发作前期开始下降,而在痫性发作期呈显著下降,与发作间期比较,发作前期与发作期的功率谱熵明显降低。致痫组痫性发作期和发作前期的功率谱熵与正常组和对照组比较差异有统计学意义(P<0.05)。结论:功率谱熵的变化揭示了痫性发作过程脑电信号复杂度的变化过程,并对痫性发作的预报提供了可能。

Objective To investigate the application of power spectral entropy（PSE） in epileptic rats induced by penicillin,and to exploreits its value in predicting epileptic seizures.Methods Eighteen SD rats were randomly divided into 3 groups： a normal group,a control group and an epileptic group.Acute chemical models were made using penicillin microinjection in the right hippocampus of rats.Sprague-Dawley（SD） rats received continuous electronencephalographic（EEG） monitoring by deep department electrode.Changes of PSE of EEG signal in the epileptic group were analysed in the whole seizure process and compared with those in the normal group and the control group.Results In the whole seizure process of the rats induced by penicillin,PSE began to decline during the pre-ictal period and dropped sharply during the ictal period.PSE in the pre-ictal and ictal period declined apparently comparing with that in the non-ictal period.PSE in the epileptic group had significant differences during the ictal and pre-ictal period compared with that in the normal group and the control group（P0.05）.Conclusion Changes of PSE reveal the changes of the complex ictal EEG signals,and may be useful to predict epileptic seizures.