足月新生儿出生体重与母婴脂联素水平的相关性研究

The relationship of newborns＇ birth weight with adiponectin levels of themselves and their mothers＇

目的探讨足月孕妇和新生儿脐静脉血中脂联素（Adiponectin）水平特点及其与新生儿体重的关系。方法采用放射免疫法测定36例健康育龄期妇女（对照组）和31例正常足月孕妇（妊娠组）及其新生儿脐静脉血（新生儿组）的血清胰岛素及脂联素水平，并进行统计学分析。结果足月孕妇血清脂联素水平最低（11．10±5．72）g／ml；新生儿脐血脂联素水平为（30．71±12．77）g/ml，妊娠组高于对照组妇女（16．52±6．87）g/ml；妊娠组脂联素水平与FINS、HOMA—IR呈负相关（r=-0．411、-0．393，P〈0．05）；新生儿脐血脂联素水平与新生儿出生体重正相关（r=0．416，P〈0．05）；母亲血清脂联素水平与新生儿脐血脂联素及出生体重无相关性。结论（1）新生儿组脂联素水平显著高于对照组及妊娠组；（2）新生儿脐血脂联素水平与其出生体重正相关，表明新生儿脂联素可能与胎儿宫内发育有关；（3）足月孕妇脂联素水平与新生儿脂联素水平、出生体重无相关性。

Objective To study the characteristics of plasma adiponectin levels exhibiting in gestation women and newborns, as well as the relationships between adiponectin levels and fetal birth weight. Methods Totally 98 subjects have been considered in this study, in- eluding venous blood samples of 36 healthy non-pregnant women （control group）, 31 uncomplicated pregnant women （pregnancies group） and the cord blood samples taken at delivery of their singleton infants born at term （newborns group）. The concentrations of adiponectin and insulin were determined by radioimmunoassay technique. And SPSS was used for statistical analyses. Results The adiponectin level in women of late period of gestation （WLPG） （11.10±5.72 ）g/ml was lower than that of other two groups, and the newborns average cord plasma level of adiponectin was （ 30. 71±12. 77 ） g/ml significantly higher than that of the control group （ 16. 52±6. 87 ） g/ml. The adipone- ctin level for WLPG was correlated with FINS and HOMA-IR （ r = - 0. 411, - 0. 393, P 〈 0. 05 ）. The adiponectin level in cord plasma was positively correlated with birth weight（ r = 0. 416, P 〈 0. 05）. The adiponectin level in WLPG was correlated neither with the adiponectin level nor body weights of their newborns. Conclusions The average cord plasma adiponeetin level of newborns is significantly higher than that of the control group and WLPG. It is positively correlated with birth weight, which suggests that adiponectin may be involved in regulating fetal growth. The adiponectin level in WLPG is correlated neither with the adiponectin level nor body weights of their newborns.