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Caveolin-1在人雄激素非依赖性前列腺癌细胞系中的表达

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摘要 目的研究人雄激素非依赖性前列腺癌PC-3和PC-3m细胞中Caveolin-1 mRNA的表达，分析Caveolin—1与前列腺癌发生发展的关系，探讨Caveolin—1表达在PC-3m具有高侵袭性和转移性中的作用。方法以PC-3和PC-3m细胞系为研究对象，采用RT-PCR检测PC-3和PC-3m细胞系中Caveolin-1 mRNA的表达。结果PC-3、PC-3m细胞中均有Caveolin-1 mRNA的表达，其在PC-3m细胞中的表达水平明显高于PC-3细胞，两者差异有统计学意义（P〈0．01）。结论Caveolin-1在人前列腺癌的侵袭和转移过程中发挥作用。
作者 廖海球 杨罗艳
机构地区 湖南省娄底市中心医院泌尿外科 中南大学湘雅二医院泌尿外科
出处 《中国医师杂志》 CAS 2009年第9期1262-1263,共2页 Journal of Chinese Physician
关键词 细胞质膜微囊蛋白/代谢 前列腺肿瘤/代谢 雄激素类
分类号 R737.25 [医药卫生—肿瘤] R363 [医药卫生—病理学]
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参考文献10

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中国医师杂志
2009年 第9期

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