铜绿假单胞菌2005年～2008年我院感染患者的各类标本分布及其耐药性分析

Hospital Infection Sample Distribution and Drug Resistance of Pseudomonas Aeruginosa in Our Hospital from 2005 to 2008

目的了解铜绿假单胞菌(PA)在本院院内感染的临床分布及其耐药情况,指导临床合理应用抗菌药物.方法采集本院2005年8月至2008年8月我院确诊的192例铜绿假单胞菌院内感染患者的各类标本,分离出铜绿假单胞菌,采用K-B纸片琼脂扩散法进行药敏试验.结果铜绿假单胞菌以痰标本中分离最高.在多种临床常用抗生素中,铜假单胞菌对亚胺培南、氨曲南敏感性最高,而耐药性较高的为头孢唑啉、呋喃妥因.结论铜绿假单胞菌对常用的抗生素耐药率较高,临床应严格遵守抗生素使用原则,合理应用抗生素.

Objective To learn the sample distribution of hospital infection and drug resistance of pseudomonas aeruginosa, to guide rational drug use in clinic. Methods We retrospectively investigated 192 cases of pseudomonas aeruginosa infection in our hospital from 2005 to 2008. Drug sensitivity test was carried out by NCCLS KB disc method recommended by WHO. Results The infection of pseudomonas aeruginosa was mainly in the respiratory tract, Among the common antibiotics in clinic, the effects of imipenem piperaeillin-tazobactam were best in the treatment of pseudomonas aeruginosa infection. Conclusions The resistance rate of pseudomonas aeruginosa on common antibiotics is high. We should abide strictly by the rules of antibiotics using and use antibiotics rationally.