血清新蝶呤在急性冠脉综合征患者中的表达

Dynamic state change of the serum neopterin levelin patients with acute coronary syndromes

目的:探讨血清新蝶呤(Npt)在急性冠脉综合征(ACS)患者中的表达。方法:选取2007年9月～2008年12月急诊就诊的急性冠脉综合征患者60例作为试验组,并按临床情况将其分为不稳定性心绞痛(UAP)组30例及急性心肌梗死(AMI)组30例,同时在本院体检中心选取30例体检正常人群作为对照组。检测实验组入院第1、3、7天和对照组血清新蝶呤水平及血脂、肝功能、肾功能等,并对各组患者及对照组检验结果进行比较。结果:入院第1天AMI及UAP组的血清Npt浓度显著高于对照组(P<0.01),而各组之间的年龄、收缩压、舒张压、血糖、血脂、肝功能、肾功能等差异无统计学意义(P>0.05)。另ACS患者入院第1天及第3天血清Npt浓度均显著高于其入院第7天血清Npt浓度(P<0.05)。结论:血清中Npt浓度的升高与急性冠脉综合征(ACS)有关,可能是不稳定斑块及ACS的预测因子。

Objective：To explore dynamic state change of the serum neopterin level （Npt）in patients with acute coronary syndromes（ACS）.Methods：30 patients with unstable angina pectoris（UAP） group and 30 patients with acute myocardial infarction （AMI） group were as experimental group,and 30 healthy persons were as normal group.Serum neopterin levels on 1 st, 3rd, 7th, day of the experimental group, and normal group were examined respectively. Results：Serum neopterin levels on 1st day of experimental group were significantly higher than those of normal group（P〈0.01）;serum neopterin level of experimental group on 1 st, 3rd day was significantly higher than that on 7th day（P〈0.05）.Conclusion：High neopterin levels is correlated with acute coronary, syndromes（ACS）.It maybe a predictor of vulnerable plaques and ACS.