载药EVA/二氧化硅复合物薄膜的制备及体外缓释性能

Preparation of Drug-Containing EVA/Silica Composite Films and Their in vitro Sustained Release Performance

采用溶胶-凝胶法制备了乙烯-醋酸乙烯酯共聚物(EVA)/二氧化硅的缓释复合材料。研究了复合材料的结构、亲-疏水性,并以阿司匹林为药物模型,考察二氧化硅添加量对聚合物缓释性能的影响。结果表明:采用溶胶-凝胶法能使二氧化硅微粒均匀分散在聚合物中;二氧化硅的加入能提高EVA载药膜的缓释性能;当二氧化硅质量分数为10%时,二氧化硅粒径为2～4μm,复合膜缓释性能最好,缓释时间超过72 h;并且复合膜的药物释放过程符合Fickian扩散定律。

Drug-releasing composites containing ethylene-vinyl acetate copolymer（EVA） /silica were prepared via sol-gel route.The structure and hydrophilic/hydrophobic property of composites were studied.Aspirin was used as a model drug and the effect of silica content on the sustained release behaviors of polymer was studied.Results show that silica can be homogeneously dispersed in the copolymers by sol-gel method and the sustained release performance of EVA is improved.When the mass fraction of silica is 10%,the silica particle size is about 2—4 μm,and the films exhibit the best sustained release performance with sustained time exceeding 72 h.The drug release behavior of the composite samples fits well with the Fickian diffusion model.