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靛红衍生物的合成 被引量：3

Synthesis of Isatin Derivatives
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摘要 以取代苯胺或者靛红为原料,通过四条不同的路线合成了一系列苯环上卤代和N-取代的靛红衍生物,最高产率达83%。其结构经NMR确认。 A series of isatin derivatives in high yields（ up to 85% ） were synthesized from substituted aniline or isatin by four methods. The structures were confirmed by NMR.
作者 廖玉华 陈文兵 张晓梅 袁伟成
机构地区 中国科学院成都有机化学研究所不对称合成与手性技术四川省重点实验室 中国科学院研究生院
出处 《合成化学》 CAS CSCD 北大核心 2009年第5期612-614,636,共4页 Chinese Journal of Synthetic Chemistry
基金 国家自然科学基金资助项目(20402074)
关键词 苯胺 靛红 Sandmeyer法 合成 aniline isatin Sandmeyer synthesis
分类号 O626 [理学—有机化学]
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参考文献7

  • 1Minami M, Hamaue N, Hirajuji M, et al.Isatin, an endogenous MAO inhibitor,and a rat model of parkinson'S disease induced by the Japanese encephalitis vires [ J ]. J Neural Transm Suppl ,2006 ,71 : 87 - 95.
  • 2Matthew G Bursavich, Adam M Gilbert, et al. 5'-Phenyl-3'H-spiro ( indolinc-3,2'-[ 1,3,4 ] thiadiazol ) -2- one inhibitors of ADAMTS-5 ( aggrecanase-2 ) [ J ]. Bioorganic & Medicinal Chemistry Letters, 2007,17 : 5630 - 5633.
  • 3Simon J Garden, Jose C Tortes, et al. A modified sandmeyer methodology and the synthesis of ( ± )- convolutamydine A [ J ]. Tetrahedron Letters, 1997,38 : 1501 - 1504.
  • 4Panagiotis Polychronopoulos, Prokopios Magiatis, et al. Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases [ J ]. J Med Chem, 2004,47 : 935 - 946.
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  • 7Ryo Shintani, Mitsunori Inoue, Tamio Hayashi. Rhodium-catalyzed asymmetric addition of aryl- and alkenylboronic acids to isatins [ J ]. Angew Chem Int Ed, 2006,45:3353 - 3356.

同被引文献37

  • 1闵真立,姜凤超,张奇.3-取代吲哚酮类化合物的合成及抗肿瘤活性[J].中国药物化学杂志,2005,15(3):129-132. 被引量：10
  • 2张陈,陆涛.2-取代-4(3H)-喹唑啉酮类化合物合成研究进展[J].精细化工中间体,2006,36(5):12-15. 被引量：5
  • 3C S Marvel, et al.Organic Syntheses[J].1925, (5):71-73.
  • 4Polychronopoulos,et al. Structural Basis for the Synthesis of Indirubins as Potent and Selective Inhibitors of Glycogen Synthase Kinase-3 and Cyclin-Dependent Kinases [J]. Journal Medicinal Che- mistry,2004, 47(4) : 935-946.
  • 5Jingrong Cao, et al. Structure-based design and parallel synthesis of N-benzyl isatin oxime as JNK3 MAP kinase inhibitors [J]. Bioorganic & Medicinal Chemistry Letters,2009, 19:2 891 - 2 895.
  • 6Stefan M Huber, et al. From DMF to Isafine: A Novel and General One-Pot Synthesis of Isatine and Its N-Unsubstituted Derivatives via Nucleophilic Substitution Reactions on 1,2-Bis(dimethylami-no)-1,2-dichloroethene [J].Joumal of Heterocyclic Chemistry,2009, 46:421-427.
  • 7Georg J Quallich, P M Morrissey. A general oxindole synthesis [J]. Synthesis,1993, 51-53.
  • 8Sharon Rossiter.A convenient synthesis of 3-methyleneoxindoles: cytotoxic metabolites of indole-3-acetic acids [J].Tetrahedron Letters, 2002, 43:4 671 - 4 673.
  • 9Erica A Kraynack, et al. An improved procedure for the regiospecific synthesis of electron deficient 4- and 6-substituted isatins[J]. Tetrahedron Letters, 1998, 43:4 671 - 4 673.
  • 10Teruhisa Tokunaga, et al. Oxindole Derivatives as Orally Active Potent Growth Hormone Secretagogues [J].Journal Medicinal Chemis- try,2001, 44(26):4 641-4 649.

引证文献3

二级引证文献2

合成化学
2009年 第5期

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