1,8-二甲氧基乙基萘的合成

Synthesis of 1,8-Bis(2-methoxylethyl)-naphthalene

以1,8-二萘酸酐为原料,经氢化铝锂还原得1,8-二羟甲基萘(2);2经浓盐酸酸化生成1,8-二氯甲基萘(3);3经氢化铝锂还原为1,8-二甲基萘(4);用强碱丁基锂和叔丁醇钾将4转化成二钾盐后与甲氧基氯甲烷反应合成了1,8-二甲氧基乙基萘,其结构经1HNMR和13C NMR和HR-MS表征。

Naphthalic anhydride was reduced to 1,8-bis （hydroxylmethyl） -naphthalene （2） by lithium aluminum hydride, then was treated by concentrated hydrochloric to form 1,8-bis （chloromethyl）naphthalene （3）. 3 was reduced to 1,8-dimethylnaphthalene （4） by lithium aluminum hydride again. 4 was transferred to the dipotassium salt of 4 and then directly reaction with chloro（methyl） methane to gain 1,8-bis （2-methoxylethyl） -naphthalene （5）. The structures were characterized by 1H NMR, 13C NMR and HR-MS.