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CYP450氧化还原酶的遗传多态对药物代谢的影响 被引量：15

Genetic polymorphisms of cytochrome P450 oxidoreductase and its effect on drug metabolism
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摘要 CYP450氧化还原酶(cytochrome P450 oxidoreductase,POR)是所有肝微粒体的细胞色素P450氧化酶(cytochrome P450 monooxygenases,CYP)的唯一电子供体,其中一些CYP是I相药物代谢酶,负责临床上超过80%药物的氧化代谢。另外,POR直接介导了一些抗肿瘤前体药物的代谢。因此,POR的遗传多态引起其活性的改变,对临床药物代谢具有非常重要的临床意义。该文总结了近年来POR的遗传多态影响药物代谢的最新研究进展。 Cytochrome P450 oxidoreductase （POR） is the only electron donor for all mierosome Cytoehrome P450 monooxygenases which are phase I metabolizing enzymes responsible for the metabolism of more than 80% drugs used in clinic. Also, POR metabolizes some anti-tumor prodrugs directly. Therefore, the alteration in POR activity caused by the polymorphisms of POR gene will be of great clinical significance. This review summarizes the newest advancement on the effects of POR polymorphisms on drug metabolism.
作者 范岚 彭向东 郭志华 周宏灏
机构地区 中南大学临床药理研究所 中南大学湘雅三医院药剂科
出处 《中国药理学通报》 CAS CSCD 北大核心 2009年第9期1131-1133,共3页 Chinese Pharmacological Bulletin
基金 国家自然科学基金资助项目(No30672497 30472054)
关键词 CYP450氧化还原酶 细胞色素P450氧化酶 药物代谢 遗传多态 药物基因组学 电子供体 cytochrome P450 oxidoreductase cytochrome P450 monooxygenases drug metabolism polymorphism pharmacogenetics eletron donor
分类号 R-05 [医药卫生] R345.99 [医药卫生—基础医学]
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  • 1Masimirembwa CM,Otter C,Berg M et al.,Heterologous expression and kinetic characterization of human cytochromes P450:validation of a pharmaceutical tool for drug metabolism research[J].Drug Metab Dispos,1999,27(10):1117-22.
  • 2Wang M,Roberts DL,Paschke R et al.Three-dimensional structure of NADPH-cytochrome P450 reductase:prototype for FMN- and FAD-containing enzymes[J].Proc Natl Acad Sci U S A,1997,94(16):p8411-6.
  • 3Shen AL et al.Structural analysis of the FMN binding domain of NADPH-cytochrome P-450 oxidoreductase by site-directed mutagenesis[J].J Biol Chem,1989,264(13):7584-9.
  • 4Paine MJ et al.Role of the conserved phenylalanine 181 of NADPH-cytochrome P450 oxidoreductase in FMN binding and catalytic activity[J].Biochemistry,2001,40(45):p13439-47.
  • 5Shen AL,Kasper CB.Differential contributions of NADPH-cytochrome P450 oxidoreductase FAD binding site residues to flavin binding and catalysis[J].J Biol Chem,2000,275(52):41087-91.
  • 6Shen AL,Sem DS,Kasper CB.Mechanistic studies on the reductive half-reaction of NADPH-cytochrome P450 oxidoreductase[J].J Biol Chem,1999,274(9):5391-8.
  • 7Hubbard PA,Liang X,Schulz H,Kim J.NADPH-cytochrome P450 oxidoreductase.Structural basis for hydride and electron transfer[J].J Biol Chem,2001,276(31):29163-70.
  • 8Gutierrez A,Lian LY,Wolf CR et al.Stopped-flow kinetic studies of flavin reduction in human cytochrome P450 reductase and its component domains[J].Biochemistry,2001,40(7):1964-75.
  • 9Murataliev MB,Feyereisen R.Mechanism of cytochrome P450 reductase from the house fly:evidence for an FMN semiquinone as electron donor[J].FEBS Lett,1999,453(1-2):201-4.
  • 10Murataliev MB,Feyereisen R.Interaction of NADP(H) with oxidized and reduced P450 reductase during catalysis.Studies with nucleotide analogu[J].Biochemistry,2000,39(17):5066-74.

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中国药理学通报
2009年 第9期

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