调控环磷腺苷信号通路治疗病理性疼痛

Controlling pathologic pain through modulating the cAMP signal pathway

病理性疼痛是困扰人类健康的一种常见疾患,寻找合适的治疗靶点控制病理性疼痛是目前疼痛研究的一个重要方向。近年的研究发现,活化的炎细胞、神经胶质细胞在病理性疼痛中发挥重要作用。环磷腺苷是存在于多种细胞内的第二信使,有文献报道促进环磷腺苷通路能抑制炎细胞及胶质细胞活性,进而治疗病理性疼痛。该文对环磷腺苷通路抑制炎细胞及胶质细胞活化的机制,以及磷酸二酯酶抑制剂治疗病理性疼痛的研究现状做一综述。

Pathologic pain is a common suffering and does great harm to people health. Therefore it is important to search some suitable targets for pain management. Recently it has been shown that activated inflammatory cells and glia are strongly implicated in the pathologic pain. Cyclic 3＇, 5＇-adenosine monophosphate, a universal intracellular second messenger, has been proven to inhibit the activity of inflammatory cells and glia by enhancing its activity, further to control pathologic pain. This review presents the current understanding of the underlying mechanisms for the inhibitive effect of cAMP signal pathway in inflammatory cells and glia, and the effect of phosphodiesterase inhibitors used for relieving pathologic pain.