摘要
肿瘤坏死因子(TNF)抑制剂在对常规治疗不敏感的炎症免疫性疾病的治疗中显示出较好疗效,但在使用过程中也出现了严重的、致命性的不良反应,包括增加恶性肿瘤、白血病、银屑病和其他免疫病的发病风险等。美国食品与药品管理局近日发布消息,要求在TNF抑制剂的处方信息中加入严重警示。医务人员需高度关注TNF抑制剂引起严重不良反应的风险,注意用药安全。
Tumor necrosis factor (TNF) blockers are promising therapeutic agents for patients with conventional therapy insensitive inflammatory diseases. Unfortunately, their use has been associated with an increased rate of malignancies, leukemia, psoriasis and other immune diseases. The U. S. Food and Drug Administration(FDA) is requiring stronger warnings in the prescribing information for TNF blockers. Healthcare Professionals should pay close attention to severe adverse effects of TNF blockers and drug safety.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2009年第9期1254-1256,共3页
Chinese Pharmacological Bulletin