艾滋病合并新型隐球菌脑膜脑炎的影像学表现

Imaging Study of Patients with Acquired Immune Deficiency Syndrome(AIDS) Complicated with Neo-cryptococcal Meningoencephalitis

目的:探讨艾滋病合并新型隐球菌脑膜脑炎的影像特点,并与非艾滋病患者新型隐球菌脑膜脑炎作对比分析。方法:回顾分析经病原学证实的12例艾滋病和14例非艾滋病合并新型隐球菌脑膜脑炎患者头颅CT及MRI的表现,比较艾滋病合并新型隐球菌脑膜脑炎与非艾滋病患者新型隐球菌脑膜脑炎的影像差别。结果:艾滋病患者局限性脑水肿和脑内强化病灶明显少于非艾滋病患者(0/10,0/10;4/9,4/7,P<0.05),VR间隙扩大、胶样假囊、脑膜强化和脑积水、脑萎缩两者间无明显差异(P>0.05)。结论:艾滋病合并新型隐球菌脑膜脑炎的影像表现与非艾滋病患者新型隐球菌脑膜脑炎相仿,但患者炎症反应的影像表现轻于非艾滋病患者,结合临床有助于艾滋病合并新型隐球菌脑膜脑炎的诊断。

Objective：To study the imaging manifestations of AIDS patients complicated with neocryptococcus meningoencephalitis（NCM） and compared with that of NCM in non-AIDS patients.Methods：The CT and MRI findings of 12 etiology proved AIDS patients and 14 non-AIDS patients with NCM were retrospectively analyzed,the differences of neuro-imaging manifestations in these two groups of patients were compared.Results：Focal cerebral edema and intra-cerebral enhanced lesions in AIDS patients were significantly less than that of non-AIDS patients（0/10,0/10;4/9,4/7 respectively,P〈0.05）.While no significant differences were revealed in enlargement of VR space,gelatinous pseudocysts,meningeal enhancement,brain atrophy and hydrocephalus in AIDS and non-AIDS patients with NCM（P〉0.05）.Conclusion：The neuro-imaging manifestations of neo-cryptococcus meningoencephalitis（NCM） were similar between the patients with AIDS and non-AIDS,but the imaging findings of intra-cerebral inflammation were less in patients with AIDS compared with that of non-AIDS patients.Neuro-imaging findings correlated with clinical materials were helpful in the diagnosis of NCM complicated in AIDS patients.