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结直肠癌组织中AKT2的表达变化及意义

Expression and significance of AKT2 protein in colorectal cancer
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摘要 目的观察结直肠癌组织中AKT2蛋白的表达,探讨其在结直肠癌预后判断中的应用价值。方法采用免疫组化SP法检测75例结直肠癌组织和20例癌旁正常组织中的AKT2。结果AKT2阳性表达在正常组织中低于结直肠癌组织(P<0.01),并与淋巴结转移、Dukes分期、浸润深度、远处转移有关(P均<0.05);AKT2阳性者的生存时间明显短于阴性者(P=0.000 7)。多因素分析结果显示,淋巴结转移、Dukes分期、远处转移和AKT2是独立的预后指标(P分别为0.013、0.018、0.001、0.038)。结论结直肠癌组织中AKT2表达上调;AKT2阳性表达与结直肠癌转移、侵袭性有关,可作为评价结直肠癌预后的指标之一。 Objective To investigate the expression and significance of AKT2 protein in colorectal cancer. Methods Immunohistochemistry was used to detect the expression of AKT2 protein in 75 colorectal carcinoma tissue and 20 normal tissues. Results The AKT2 expression in normal tissue was lower than in colorectal cancer tissues, and had something to do with lymph node metastases, Dukes stage, depth of invasion, distant metastasis （ P 〈 0.05 ） ; The survival time of AKT2 positive patients was significantly shorter than the negative （ P = 0. 000 7 ）. Lymph node metastases, dukes stage , distant metastasis and AKT2 were independent prognostic factor （P = 0. 013,0. 018,0. 001,0. 038 ）. Conclusions AKT2 expression raises in colorectal cancer tissue; AKT2 positive expression relates to metastasis and invasion of colon cancer. AKT2 can be used as an indicator of prognosis in colorectal cancer.
作者 杜坤庭 葛勤利 杨伟捷 罗菲 万顺梅
机构地区 中国人民解放军第一医院
出处 《山东医药》 CAS 北大核心 2009年第34期6-8,共3页 Shandong Medical Journal
关键词 结直肠肿瘤 蛋白激酶B 预后 colorectal neoplasm protein kinase B prognosis
分类号 R735.3 [医药卫生—肿瘤]
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参考文献10

  • 1Vivanco I,Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer[J]. Nat Rev Cancer,2002, (7) :489-501.
  • 2Sun M, Paciga JE, Feldman RI, et al. Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2 ,activated in breast cancer,regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K[ J]. Cancer Res,2001,61 (16) :5985-5991.
  • 3Fresno-Vara JA, Casado E, de Castro J, et al. PI3K/Akt signalling pathway and cancer [ J ]. Cancer Treat Rev, 2004,30 ( 2 ) : 193 -204.
  • 4Arboleda MJ, Lyons JF, Kabbinavar FF, et al. Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of betal integrins, increased invasion, and metastasis of human breast and ovarian cancer cells[ J]. Cancer Res ,2003,63 ( 1 ) : 196-206.
  • 5Izuishi K, Kato K, Ogura T, et al. Remarkable tolerance of tumor cells to nutrient deprivation: possible new biocbemical target for cancer therapy[ J ]. Cancer Res,2000,60 (21 ) :6201-6207.
  • 6Xu X, Sakon M, Nagano H, et al. Akt2 expression correlates with prognosis of human hepatocellular carcinoma [ J ]. Oncol Rep,2004, 11(1) :25-32.
  • 7Yamamoto S, Tomita Y, Hoshida Y, et al. Prognostic significance of activated Akt expression in pancreatic duetal adenoeareinoma[J]. Clin Cancer Res ,2004,10( 8 ) :2846-2850.
  • 8Rychahou PG, Kang J, Gulhati P, et al. Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis [ J]. Proc Natl Acad Sci USA ,2008,105(51 ) :20315-20320.
  • 9汪鑫,聂绍发.应用COX比例风险模型对大肠癌切除术后预后影响因素的分析[J].肿瘤防治研究,2006,33(4):286-287. 被引量：7
  • 10傅深,章青,邵雨卉,陈海泉.抑制生存传导路径可增加肿瘤细胞化疗敏感性[J].中国癌症杂志,2005,15(2):135-137. 被引量：1

二级参考文献12

  • 1David O, Jett J, LeBeau H, et al. Phospho-Akt overexpression in non-small-cell lung cancer confers significant stage-independent survival disadvantage [ J ]. Clin Cancer Res, 2004,10 ( 20 ):6865-6871.
  • 2Frank TF, Kaplan DR, Cantley LC. PI3K: Downstream AKTion blocks apoptosis [ J ]. Cell, 1997,88 ( 4 ) :435-437.
  • 3Downward J. PI3-kinase, Akt and cell survival [ J ]. Semin Cells Devel Biol,2004,15(2) :177-182.
  • 4Brognard J, Clark AS, Ni Y, et al. Akt/protein kinase B is constitutively active in non-small-cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation [ J ]. Cancer Res ,2001,61 (10) :3986-3997.
  • 5Perez-Tenorio G, Stal O. Southeast Sweden Breast Cancer Group. Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients [ J ]. Br J Cancer,2002,86(4) :540-545.
  • 6Bergman PJ. Mechanisms of anticancer drug resistance[J]. Vet Clin North Am Small Anim Pract, 2003,33(3) :651-667.
  • 7Gagnon V, Mathieu I, Sexton E,et al. AKT involvement in cisplatin chemoresistance of human uterine cancer cells [ J ]. Gynecol Oncol,2004,94( 3 ) :785-795.
  • 8Terakawa N, Kanamori Y, Yoshida S. Loss of PTEN expression followed by Akt phosphorylation is a poor prognostic factor for patients with endometrial cancer [ J ]. Endocr Relat Cancer,2003,10(2): 203-208.
  • 9Galindo Gallego M, Fernandez Acenero MJ, Sanz Ortega J, et al. Vascular enueration as a prognsticator for colorectal carcinoma[J]. Eur J Cancer,2000,36(1) : 55-60.
  • 10Massacesi C, Norman A, Price T, et al. A clinical nomogram for predicting long-term survival in advanced colorectal cancer[J]. Eur J Cancer, 2000, 36(16):2044-2052.

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山东医药
2009年 第34期

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