水相中钯催化4-氟苯硼酸与2-溴吡啶的Suzuki偶联反应

Pd-Catalyzed Suzuki Cross-Coupling Reactions of 4-Fluorophenylboronic Acids with 2-bromopyridine in Water

以Pd2(dba)3作为催化剂,对2-溴吡啶和4-氟苯硼酸进行了Suzuki偶联反应,合成了相应的偶联产物2-(4-氟苯基)吡啶,并利用单因素法考查了反应中所用的碱、溶剂、相转移催化剂等因素对反应的影响,探索其最佳反应条件。最佳反应条件是碱为KOH,溶剂为水,相转移催化剂为十六烷基三甲基溴化铵。

2-（4-fluoro-phenyl）pyridine was synthesized via Suzuki cross-coupling reaction of 2-bromopyridine and 4-fluorobenzeneboronic acids by using Pd2（dba）3 as catalyst, and the influences of some reaction factors including solvents, bases and phase transfer catalysts （PTC） on the reaction were discussed and the optimum condition was determined through single-factor approach. The optimum reaction condition was KOH as base, water as solvent, POPd as catalyst, and hexadecyl trimethyl ammonium bromide as PTC.