白细胞介素-17水平升高在急性冠脉综合征患者中的临床意义

Level of serum interleukin - 17 in the patients with acute coronary syndrome and its clinical significance

目的探讨白细胞介素-17（IL-17）水平在急性冠脉综合征（ACS）发病中的作用及可能途径。方法ACS患者50例，包括不稳定型心绞痛（UAP）34例、急性心肌梗死（AMI）16例；稳定型心绞痛（SAP）21例；健康对照者10例。ELISA法检测血清IL-17水平。结果AMI组和UAP组IL-17水平较SAP组和正常对照组明显增高（P〈0.05）；根据不同组别的亚组分析发现，不稳定型斑块组IL-17水平较稳定型斑块组明显增高（P〈0．05）。冠脉病变支数与IL-17水平无关，各组水平比较差异无统计学意义（P〉0．05）。结论ACS患者血清IL-17水平增高，IL-17有望作为ACS斑块稳定性的预测因子。

Objective To investigate the serum level of interleukin （ IL） - 17 in the patients with acute coronary syndrome （ ACS）. Methods Serum IL - 17 levels in 50 cases With ACS including 34 cases of unstable angina pectoris （UAP） and 16 cases of acute myocardial infarction（ AMI） , 21 cases of stable angina pectoris （ SAP） and 10 cases of normal controls were determined by enzyme - linked immunosorbent assay （ ELISA）. Results Serum level of IL - 17 were significantly higher in AMI and UAP than in SAP group and normal group （ P 〈 0. 05）. There was no significant difference between SAP and normal controls （ P 〉 0. 05 ） , but there was significant difference between unstable plaque subgroup and stable plaque subgroup （ P 〈 0. 05 ）. Among acute coronary syndrome group, IL - 17 level of the patients with stenosis lesion in 2 or 3 branches of coronary artery had no significant difference （ P 〉 0. 05 ）. Conclusion IL - 17 level increased in the patients with acute coronary syndrome and could be used as valuable parameters for the progression and stability of the atheroma.