摘要
目的探讨不同剂量重组人促红细胞生成素（recombinant human erythropoietin，rHu—EPO）对心肌梗死大鼠血流动力学和左室梗死面积的影响。方法选取成年SD大鼠64只，随机分为假手术组、心肌梗死对照组、大剂量治疗组和小剂量治疗组。各组分别于术后24h和2周检测血流动力学指标和左室梗死面积。结果术后24h：与假手术组相比，心肌梗死对照组LVSP、LVEDP和±dp／dtmax显著恶化；与心肌梗死对照组相比，大、小剂量治疗组±dp／dtmax有显著改善。术后2周：与暇手术组相比，心肌梗死对照组LVSP、LVEDP和±dp／dtmax显著恶化；与心肌梗死对照组相比，大、小剂量治疗组±dp／dtmax有显著改善，梗死面积显著缩小；与大剂量治疗组相比，小剂量治疗组±dp／dtmax有显著改善。结论心肌梗死后即刻给予大剂量rHu—EPO，并术后减量维持治疗1周可明显缩小梗死面积，保护心功能，小剂量维持治疗的改善心功能效果更好。
Objective To investigate the effect of recombinant human erythropoietln [ rHu - EPO） in different doses on hemodynamic status and infarct size of left ventricle in rats with myocardial infarction. Methods Adult SD rats were divided randomly into 4 groups ： sham group （ Sham ） , myocardial infarction group（MI） , treatment group with high dose （MITH）, treatment group with low dose （ MITL）. Hemodynamic parameters and infarct size were tested 24 hours and 2 weeks after operation for all groups. Results 24 hours after operation, LVSP, LVEDP and ± dp/dtmax in MI group were significantly worse than those in Sham group, while ＋ dp/dtmax in the two treatment groups were remarkably better than those in MI group. 2 weeks after operation, MI group showed significantly worse LVSP, LV- EDP and ± dp/dtmax than Sham group, while compared with MI group the two treatment group demonstrated remarkably improved ± dp/dtmax and significantly decreased infarct size （P 〈 0.05 ）. ± dp/dtmax in MITL group were remarkably better than those in MITH group. Conclusion High dose of rHu - EPO immediately after myocardial infarction and maintenance treatment with low dose for one week can significantly reduce infarct size and protect cardiac function. For maintenance treatment, rHu - EPO in low dose leads to better cardiac function than high dose.
出处
《中国急救医学》
CAS
CSCD
北大核心
2009年第10期898-901,共4页
Chinese Journal of Critical Care Medicine
基金
基金项目：国家自然科学基金（No.30600233
30672206）
