胰头癌遗传易感性与EGF61＊G／G基因型的关系

Relationship between the genotype of EGF 61 ＊ G/G and the genetic susceptibility to pancreatic head cancer

目的通过研究表皮生长因子（EGF）61＊G／A基因功能多态性了解EGF因子对胰头癌生成的影响。方法采用聚合酶链反应-限制性片段长度多态性（PCR—RFLP）方法检测胰头癌组及正常对照组的EGF61＊G／A基因型。结果胰头癌患者EGF61％G／G基因型或61＊G等位基因明显高于对照组，其差异有统计学意义（基因型x^2=6．042，P〈0．05，OR=2．618，95％CI=1．195～5．738；等位基因x^2=6．007，P〈0．05，OR=1．696，95％CI=1．110～2．592）。结论EGF61＊G／G基因型或61＊G等位基因与胰头癌的生成相关。

Objective To understand the effect of EGF on the development of pancreatic head cancer by investigating the EGF 61 ＊ G/A gene functional polymorphism. Methods PCR-RFLP was employed to study the EGF 61 ＊ G/A genotypes in pancreatic head cancer patients and healthy controls. Resuits The frequency of EGF 61 ＊ G/G genotype and G allele was significantly higher in patients with pancreatic head cancer than in healthy controls （ genotype x^2 = 6. 042 ,P 〈 0.05, OR = 2. 618,95% CI = 1.195-5. 738 ; allele x^2 =6. 007,P 〈0.05,OR = 1. 696,95% CI = 1. 110-2. 592）. Conclusion EGF 61 ＊ G/G genotype and G allele are significantly related to the development of pancreatic head cancer.