柠檬酸铝和羟基磷酸喹哌联合治疗矽肺疗效观察

Clinical Observation on Combined Treatment with Aluminum Citrate and Hydroxypiperaquine Phosphate in Silicosis

用柠檬酸铝和羟基磷酸喹哌治疗矽肺病人40例，20例病人给安慰剂作为对照，进行了2年6个疗程的治疗对比观察。结果发现两组病人临床症状均有不同程度改善，X线胸片结果表明治疗组37例（有3例因出现合并病未统计）中治疗后有好转与明显好转共4例，占10．81％，1例有进展，而对照组20例中无1例好转，进展与明显进展共5例，占25％，两组比较差异显著（P＜0．05）。用综合疗效评价指标发现两组差异非常显著（P＜0．001）。在治疗期间未发现明显毒副作用，说明用柠檬酸铝和羟基磷酸喹哌联合治疗矽肺的方法是有效而安全的，宜推广应用。

40 silicosis cases were treated with Aluminum Citrate and Hydroxypiperaquine Phos phate for two years. 20 silicosis cases were treated with placebo as control group. The resultsshowed that the clinical symptoms in the treated and control group were improved at some different degree. 4 cases treated were evidently improved in the chest X-rat films of 37 cases treated,ex cept 3 cases with complications,the improving rate reached 10. 81 %,only one case treated was pro gressire. Whereas among 20 control cases,non of them was improved and 5 progressive cases werefound,accounting for 25%. The improving rate in treated group was significantly higher that incontrol group(p＜0. 05). The results indicated that the method of the combined treatment with A luminum Citrate and Hydroxypiperaquine Phosphate in silicosis was secure and effective,suggesting the method could be widely implied to treat silicosis cases.