男性免疫性不育的病理变化观察

The pathological changes of male immunologic infertility

本文采用免疫组化法观察６７例无精子症病人睾丸组织中免疫球蛋白的情况，探讨睾丸的免疫病理改变。结果发现睾丸组织中免疫球蛋白阳性ＩｇＧ、ＩｇＡ分别为２７例，ＩｇＭ２４例。免疫球蛋白沉积于生精小管壁基底膜、生精细胞和间质血管壁，其中生精细胞表面ＩｇＧ阳性１０例。我们认为免疫球蛋白沉积于生精小管壁基底膜、生精细胞表面，直接影响睾丸的生精功能，是男性免疫性不育的机制之一。

testical pathological sections of nonobstrutive azoospermia patients were studied by ABC immunohistochemistry to explain the immune mechanism of infertility. The immunohistochemistry result: IgG(+)27; IgA(+)27; IgM(+)24; The immunoglobuins deposite principly in seminiferous tubules wall basement membranes and interstitial blood vessel basement membranes. There are 10 samples inwhich IgG(+) on spermatogonia and spermatocytes. The results showed that the deposites of immunoglobuin on germcells or the basement membranes of seminiferous tubules and interstitial blood vessels damage the testis spermtogenesis.