人月经周期子宫内膜雌、孕激素受体的变化

Immunohistochemical Analysis of Human Uterine Es-trogen and Progesterone Receptors during the Men-strual Cycle

为了进一步了解人雌、孕激素受体(ER、PR)在子宫内膜周期性的变化,采用ABC免疫组织化学方法,测定了全切子宫组织的ER和PR。结果显示ER、PR在腺体、间质及肌层中的分布不完全相同,并呈现周期性的变化。腺上皮中PR的变化较明显,分泌晚期PR消失。间质及肌层中ER、PR的变化不如腺上皮明显,但在分布上也存在着疏密的变化。月经周期中子宫内膜ER、PR的这些变化提示:依赖于性甾休激素的组织在生长与分化中可能是通过受体的变化来调节其功能。

Objective: To observe changes of estrogen and progesterone receptors(ER, PR) in human endometri-um during the menstrual cycle. Methods: The endome-trial ER and PR were localized by immunohistoche-mical technique. Results: There was a cyclic change in the distribution of the ER and PR in glandular epithelium ,stroma and myometrium. The distribution of PR in the glandular epithelium showed cyclic change markedly. Intensities of PR staining in glandular cells decreased in the late secretory phase. In contrast, the cyclic changes in the distribution of the ER and PR were not obvious in the stroma and myometriun. Conclusion: These results indicated that the endometrical functions of proliferation and differentiation depending on steroid might be regulated by alteration of receptors.