运动神经元病血清抗神经节苷脂抗体的检测及临床意义

Serum anti-GMl ganglioside antibodies in motor neuron diseases patients

本研究用ELISA法初步检测了MND各类型，其它神经系统疾病（OND）及非神经系统免疫性疾病（NID）血清中抗GM1抗体的反应性。发现MND患者与正常对照组抗GM1抗体反应性有显著差异。26例中有8例（38％）MND患者抗GM1抗体滴度明显高于正常对照组，MND患者与OND对照组抗GM1抗体A值有显著差异。在部分NID息者也存在较高滴度的IgM抗GM1抗体。运动神经元病（MND）病因学说尚无统一认识。进一步开展抗CM1抗体的检测、阐明其在运动神经元疾病各亚型中的分布规律及反应性有助于深入研究其发病机制及治疗。

Antibodies of the IgM class against GM1 gangliosides were determined by an enzyme linked immunosorbent assay(ELISA) in the sera of patients with motor neuron disease(MND),other neurological diseases(OND), non-neural immune diseases(NID) and healthy individuals.Eight of 26patients with MND had increased titers of Gml IgM antibodies compared to hea1thy individual and OND patients.Some of NID patients also had elevated c0ncentration of GM1 antibodies.Further study is needed to identify the distribution of GMl antitheies in subgroup of MND and to investigate the pathogenetic mechanism of GM1 antibodies in MND.