摘要
目的探讨胃肠道间质瘤（GIST）的临床表现、诊断和治疗方法以及与预后相关的因素。方法回顾性分析79例发生于胃的GIST的临床和病理资料，分析影响预后的相关因素。结果临床表现无特异性，多通过超声内镜、CT、消化道钡餐造影等影像学检查发现肿瘤，明确诊断需通过病理组织学及免疫组化检查，79例中，CD117＋ 73例（93％）、CD34＋ 466例（83％），经手术治疗5年生存率83％，5年无瘤生存率72％。结论发生于胃的GIST首选治疗方法是手术切除，肿瘤出血、坏死及Fletcher分型是影响预后的重要指标。
Objective To investigate the clinical manifestations, diagnosis, prognosis and treatment of gastric stromal tumors （GIST）. Methods The Clinical and pathological data including immunohistochemical results of 79 patients with GIST of stomach from Aug 2000 to Aug 2003 were collected, and the clinical and pathological data were analyzed retrospectively. Results The clinical manifestations of GIST were nonspecific. Tumors could be found out by EUS, CT, and barium meal examination. Immunohistochemical staining and pathohistology was necessary for the diagnosis of GIST. In 79 cases GIST, CD,7 staining was positive in 93 % cases, and CD34 was in 83 %. The 5-year survival rate was 83 %. The 5-year tumor-free survival rate was 72 %. Conclusion Surgical resection is the standard treatment for non metastatic GIST. Tumors with necrosis, bleeding and high GIST in Fletcher＇ types are poor prognosis factors.
出处
《肿瘤研究与临床》
CAS
2009年第9期591-593,共3页
Cancer Research and Clinic
关键词
胃肠道间质瘤
临床表现
预后
治疗
Gastrointestinal stromal tumor
Clinical manifestations
Prognosis
Surgical management
