冠状动脉造影评价静脉溶栓治疗急性心肌梗塞100例临床疗效

A clinical study of 100 patients with acute myocardial infarction treated by intravenous thrombolytic therapy through coronary angiography

目的 我院自 1 994年 3月至 1 997年 6月对 1 0 0例急性心肌梗塞 (AMI)病人应用国产尿激酶 (UK)和德国链激酶 (SK)静脉溶栓治疗 ,以冠状动脉造影结果评价其疗效及安全性。结果发现 :UK和SK血管开通率分别为 60 8%及 63 0 % ,5周死亡率分别为 8 6%及 7 4 % ,严重出血并发症分别为1 85%及 2 1 7% ,均无统计学意义。 1 0例加大UK剂量至 2 0 0万U ,并不增加血管开通率反而增加出血并发症。临床观察证明UK和SK用于静脉溶栓治疗AMI是安全有效的。两者均能明显降低AMI的死亡率 ,来自溶栓治疗的严重并发症也是罕见的。

To analyse angiographic results of 100 patients with AMI who received urokinase or streptokinase for thrombolysis from March 1994 through June 1997 Coronary angiography was performed in all erolled patients within 2 hours from thrombolytic therapy The results showed the patency rate of infarct related artery are 60 8% and 63% in group UK and SK respectivety ( P >0 05) The mortality within five weeks are 8 6% and 7 4% in group UK and SK respectively ( P >0 05) The intracranial hemorrhage are 1 85% and 2 17% in group UK and SK respectively ( P >0 05) The side effects in the SK group were chill (5 5%) hypotension (7 4%) and mild bleeding tendency (37%) In group UK,increased its dosage to 2 000 000 U,the rates of reperfusion aren′t increased,but bleeding tendency increased It was suggest that UK and SK are safe and effective on intravenous thrombolytic therapy in AMI