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抗GM_1抗体和抗脑磷脂抗体与运动神经元疾病

Anti-ganglioside GM_1 Antibodies and Anti-cephalin Antibodies in Patients with Motor Neuron Diseases
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摘要 目的通过分析运动神经元疾病MND)患者血清中抗神经节苷脂GM1抗体和抗脑磷脂抗体,探讨MND的免疫机制。方法用ELISA法测定了22例MND患者血清的抗神经节苷脂GM1抗体和抗脑磷脂抗体。结果MND患者抗GM1抗体阳性7例(32%),抗脑磷脂抗体阳性5例(23%),两种抗体均阳性者2例(9%);在下运动神经元损害为主的MND(U+L-MND)患者16例中,7例(44%)抗GM1抗体阳性,5例(32%)抗脑磷脂抗体阳性,而上运动神经元损害的MND(U-MND)患者中二种抗体阳性率均为17%(1例),两者比较亦有显著性差异(P<0.01)。结论MND可能与自身免疫功能失调有关,尤其在L-MND和U+L-MND中,自身免疫机制可能参与其疾病的发生和发展。 in order to study the role of Anti-gangliosides GM1 antibodies and anticephalin antibodies in the immuno-pathogenesis of motor neuron diseases (MND). Methods Anti-gangliosides GM1 antibodies and anti-cephalin antibodies in serum were detected in 22 patients with MND by ELISA assay. Results 7 cases (32 % ) were found anti-GM,antibodies positive, while 5 cases (23 % ) were found anti-cephalin antibodies positive. 2 cases (9 % ) were positive both in anti-GM, and anti-cephalin assays. of 16 cases with MND were/predominated by symptoms of lower motor neuron damage (U-L-MAD), 7 cases (44 % ) were positive in anti-GMI antibodies assay and 5 cases (32% ) in anti-cephalin antibodies assay. Of MND patients with upper motor neuron damage, rate of both positive antibodies were 17 % (1 case). Result showed statistical significance existent between U + L-MND and L-MAD (P<0. 01). Conclusion The results indicated that autoimmunity might play a role in the pathogenesis and development of the L-MND and U +L-MND.
出处 《中国神经免疫学和神经病学杂志》 CAS 1998年第3期148-151,共4页 Chinese Journal of Neuroimmunology and Neurology
关键词 运动神经元疾病 抗体 神经节苷脂 GM1 脑磷脂 motor neuron disease antibodies gangliosidcs GM_1 cephalin
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