抗GM_1抗体和抗脑磷脂抗体与运动神经元疾病

Anti-ganglioside GM_1 Antibodies and Anti-cephalin Antibodies in Patients with Motor Neuron Diseases

目的通过分析运动神经元疾病MND）患者血清中抗神经节苷脂GM1抗体和抗脑磷脂抗体，探讨MND的免疫机制。方法用ELISA法测定了22例MND患者血清的抗神经节苷脂GM1抗体和抗脑磷脂抗体。结果MND患者抗GM1抗体阳性7例（32％），抗脑磷脂抗体阳性5例（23％），两种抗体均阳性者2例（9％）；在下运动神经元损害为主的MND（U＋L－MND）患者16例中，7例（44％）抗GM1抗体阳性，5例（32％）抗脑磷脂抗体阳性，而上运动神经元损害的MND（U－MND）患者中二种抗体阳性率均为17％（1例），两者比较亦有显著性差异（P＜0．01）。结论MND可能与自身免疫功能失调有关，尤其在L－MND和U＋L－MND中，自身免疫机制可能参与其疾病的发生和发展。

in order to study the role of Anti-gangliosides GM1 antibodies and anticephalin antibodies in the immuno-pathogenesis of motor neuron diseases (MND). Methods Anti-gangliosides GM1 antibodies and anti-cephalin antibodies in serum were detected in 22 patients with MND by ELISA assay. Results 7 cases (32 % ) were found anti-GM,antibodies positive, while 5 cases (23 % ) were found anti-cephalin antibodies positive. 2 cases (9 % ) were positive both in anti-GM, and anti-cephalin assays. of 16 cases with MND were/predominated by symptoms of lower motor neuron damage (U-L-MAD), 7 cases (44 % ) were positive in anti-GMI antibodies assay and 5 cases (32% ) in anti-cephalin antibodies assay. Of MND patients with upper motor neuron damage, rate of both positive antibodies were 17 % (1 case). Result showed statistical significance existent between U + L-MND and L-MAD (P＜0. 01). Conclusion The results indicated that autoimmunity might play a role in the pathogenesis and development of the L-MND and U +L-MND.