摘要
本文从三个方面探索了爱普列特（Ｅｐｒｉｓｔｅｒｉｄｅ）的生殖毒性。ＳＤ大鼠口服９周爱普列特后合笼，观察交配率、怀孕率和胎仔的发育情况；小鼠口服高剂量爱普列特后对精子形态的影响；体外电刺激对小鼠输精管收缩的影响。结果表明高剂量虽使大鼠怀孕率略有下降，小鼠精子的形态有所影响外，但统计无显著性差别，其他指标均属正常。
Epristeride is an uncompetitive 5α reductase inhibitor, using for treatment of benign prostatic hyerplasia. Fertility study on epristeride was carried out in SD rats. Epristeride was given to male rats for 9 weeks before mating performance at dose level of 3,15,75 mg/kg. Body weight gain and food intake were similar to control. No influence of epristeride in mating performance was observed, but showing slight less of pregnancy rate. No external, visceral and skeletal anomalies were found in fetuses. A little bit of increase in abnormal sperm morphology was observed from epristeride treated mice at high dose, but there is no statistical significant. Epristeride did not inhibit the electrically evoked contractions of mouse vas deferens. In conclusion, there is a wide range of safety in reproduction for Epristeride.
出处
《癌变．畸变．突变》
CAS
CSCD
1998年第5期286-289,共4页
Carcinogenesis,Teratogenesis & Mutagenesis
关键词
爱普列特
生殖毒性
精子畸形
前列腺
Epristeride
reproductive toxicity
abnormal sperm
prostate gland
