摘要
给小鼠吸入７０号汽油３０ｄ、６０ｄ、９０ｄ，动态观察了不同剂量的汽油（２５０ｍｇ／ｍ３、５００ｍｇ／ｍ３、１０００ｍｇ／ｍ３）对小鼠骨髓细胞染色体畸变（ＣＡ）及微核（ＭＮ）的影响。结果小鼠吸入汽油９０ｄ，在剂量为１０００ｍｇ／ｍ３的浓度下，染色体畸变率与阴性对照有非常显著差异（Ｐ＜０００５）；而小鼠骨髓嗜多染红细胞微核试验在小鼠吸入汽油６０ｄ时高剂量下（１０００ｍｇ／ｍ３），９０ｄ时中剂量（５００ｍｇ／ｍ３）、高剂量（１０００ｍｇ／ｍ３）下与阴性对照有显著性差异（Ｐ＜００１、Ｐ＜００５、Ｐ＜０００５）。
The influence of a long-term exposure to 70 gasoline on chromosomes and micronuclei in bone marrow cells of mice was investigated. The animals were exposed to 70 gasoline at low (250mg/m 3), medial (500mg/m 3) and high (1000mg/m 3) doses for 30 60 90d. After exposure for 90d (at high dose/1000mg/m 3), the frequency of CA was significantly higher than that in the negative control group. However, after exposure ofr 60d (at high dose) and 90d(at mid/high doses), the frequency of micronuclei in polychromatic erythrocytes was significantly higher than that in the negative control group. The data suggested that chronic exposure to gasoline may be hazardous to chromosome in bone marrow cells of mice.
出处
《癌变．畸变．突变》
CAS
CSCD
1998年第5期289-293,共5页
Carcinogenesis,Teratogenesis & Mutagenesis
关键词
汽油
染色体畸变
微核
实验
Gasoline
Chromosome Aberration
Micronuclei
