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罗红霉素干混悬剂生物利用度实验研究 被引量:1

The research on bioavailability of dried suspention of roxithromycin
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摘要 选择10名男性自愿者,随机分组,分别口服吉林省龙井制药厂研制的罗红霉素干混悬剂(供试品)和法国罗素优克福公司生产的罗红霉素混悬剂(对照品),采用微生物法测定供试品和对照品不同时间的血药浓度,计算供试品和对照品主要药物动力学参数.试验结果表明,两者主要药物动力学参数及生物利用度无显著性差异. Ten healthy male volunteers were randomly divided into two groups.The treatment group took the dried suspention of roxithromycin manufactured by Longjing Pharmaceutical Factory in Jilin Province,and the control group took the suspension of roxithromycin prepared in France.The blood drug concentrations of different times were measured by microbiological method in order to compare the pharmacokinetic parameters between the two groups.The results indicated that there was no significant difference in pharmacokinetic parameters and bioavailibility between the both kinds of preparation.
出处 《延边大学医学学报》 CAS 1998年第3期167-170,共4页 Journal of Medical Science Yanbian University
关键词 罗红霉素 生物利用率 药代动力学 roxithromycin pharmacology biological availability
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