抵抗素和高敏C反应蛋白诊断急性阑尾炎的价值探讨

VALUE OF RESISTIN AND HIGH-SENSITIVE C-REACTIVE PROTEIN IN DIAGNOSIS OF ACUTE APPENDICITIS

目的探讨抵抗素和高敏C反应蛋白(Hs-CRP)的检测在急性阑尾炎诊断中的价值。方法采用酶联免疫吸附法(ELISA)检测血清抵抗素含量,同时采用免疫比浊法对血清Hs-CRP进行测定;将三组阑尾炎患者(急性坏疽性阑尾炎35例,急性化脓性阑尾炎48例,急性单纯性阑尾炎32例)和阑尾无炎症患者(30例)血清抵抗素和Hs-CRP水平进行比较。结果三组急性阑尾炎患者与阑尾无炎症患者比较,血清抵抗素和Hs-CRP水平均明显升高(P<0.01);急性坏疽性阑尾炎及急性化脓性阑尾炎与急性单纯性阑尾炎比较,血清抵抗素和Hs-CRP水平明显升高(P<0.01)。同时急性阑尾炎患者抵抗素浓度与Hs-CRP浓度呈正相关(r=0.59,P<0.01)。结论在临床症状及白细胞计数升高的基础上,结合血清抵抗素和Hs-CRP水平的测定对急性阑尾炎的诊断具有一定价值。

Objective To analyze the value of resistin and highsensitive C - reactive Protein（hs - CRP ） in diagnosis of acute appendicitis. Methods The resistin and hs- CRP in serum of no inflammation cases and three groups of acute appendicitis were examined respectively. Concentrations of resistin were determined by enzyme linked immunosorbent assay （ ELISA ） ,and hs- CRP was determined by rate nephelometry immunoassay. Results The serum resistin and hs - CRP level in three groups of acute appendicitis were much higher than that in the no inflammation eases with a significant difference （ P〈0.01 ） ; the serum resistin and hs - CRP level in patients with suppurative and gangrenous appendicitis were much higher than those in patients with simple appendicitis （P〈0.01）. There was positive correlation between the concentrations of resistin and hs - CRP （r = 0. 59 , P〈0. 01 ）. Conclusion The serum resistin and hs - CRP test are valuable in diagnosis of acute appendicitis on the basis of the clinical symptom and WBC levels.