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孟鲁司特联合布地奈德治疗老年支气管哮喘临床观察 被引量:39

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摘要 目的观察孟鲁司特联合布地奈德治疗老年支气管哮喘的临床疗效。方法选取中、重度支气管哮喘急性发作的老年患者42例(年龄>60岁),其中男22例,女20例,随机分为对照组和治疗组各21例。两组均采用抗生素、多索茶碱、0.9%盐水3ml+布地耐德2mg2次/d、0.9%盐水3ml+硫酸特布他林1ml2次/d雾化吸入治疗,治疗组在此基础上加用孟鲁司特10mg每日睡前口服。疗程均为10d。记录患者住院期间白天及夜间哮喘症状发作次数,观察两组的临床症状缓解时间。两组治疗前、治疗后10d各进行1次肺功能测定,同时记录两组出院后的再住院率。结果孟鲁司特联合吸入布地奈德可以有效地改善重度老年哮喘患者的肺功能指标。治疗组患者白天发作次数、夜间发作次数均小于对照组,且患者咳嗽、喘息、胸闷等临床症状缓解时间明显短于对照组。治疗组再住院率明显小于对照组。结论孟鲁司特联合布地奈德治疗老年支气管哮喘,可以明显提高临床治疗效果。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2009年第18期2305-2307,共3页 Chinese Journal of Gerontology
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  • 1王彦,王长征,林科雄,钱桂生,卓文磊,王金平,赵志强,江汉,李淑萍.吸入糖皮质激素(ICS)联合茶碱及双倍剂量ICS治疗中重度支气管哮喘的对照研究[J].中华内科杂志,2004,43(9):710-711. 被引量:8
  • 2李国平,熊瑛,罗光燕,王宋平,王文军,李万成,王荣丽.小剂量茶碱联合氟替卡松治疗激素低敏感型支气管哮喘患者的机制探讨[J].中华结核和呼吸杂志,2004,27(8):562-564. 被引量:20
  • 3Steinshamn S, Sandsund M, Sue-Chu M, et al. Effects of montelukast on physical performance and exercise economy in adult asthmatics with exercise-induced bronchoconstriction[J]. Scand J Med Sci Sports , 2002, 12(4):211-217.
  • 4Niewoehner DE. Montelukast improved pulmonary function and asthma-specific quality of life in aspirin-intolerant asthma[J]. ACP J Club, 2002, 137(1):20.
  • 5Zhang J, Yu C, Noonan G, et al. Effect of montelukast, a once-daily leukotriene receptor antagonist, on peak expiratory flow variability[J]. Clin Ther, 2002, 24(4):574-582.
  • 6Stelmach I, Jerzynska J, Kuna P. A randomized, double-blind trial of the effect of treatment with montelukast on bronchial hyperresportsiveness and serum eosinophilic cationic protein (ECP), soluble interleukin 2 receptor ( sIL-2R), IL-4, and soluble intercellular adhesion molecule 1(sICAM-1) in children with asthma[J]. J Allergy Clin Immunol, 2002, 109(2) :257 - 263.
  • 7Dempsey O J, Kennedy G, Lipworth BJ. Comparative efficacy and anti-inflammatory profile of once-daily therapy with leukolriene antagonist or low-dose inhaled corticosteroid in patients with mild persistent asthma [ J ]. J Allergy Clin Immunol, 2002, 109(1):68-74.
  • 8Phipatanakul W, Nowak-Wegrzyn A, Eggleston PA, et al.The efficacy of montelukast in the treatment of cat allergen-induced asthma in children[J]. J Allergy Clin Immunol,2002, 109(5) :794 - 799.
  • 9Henderson WR Jr, Tang LO, Chu SJ, at al. A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model[J]. Am J Respir Crit Care Med, 2002, 165(1):108- 116.
  • 10Fregonese L, Silvestri M, Sabatini F, et al. Cysteinyl leukotrienes induce human eosinophil locomotion and adhesion molecule expression via a CysLT1 receptor-mediated mechanism[J]. Clin Exp Allergy, 2002, 32(5):745 -750.

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