肿瘤血管异质性的研究进展

Progression of heterogeneity of tumor vascular

肿瘤的生长和转移离不开血管生成。受肿瘤微环境的影响,肿瘤血管在形态、功能、蛋白表达、对细胞因子的反应性,以及在遗传学水平上与正常血管存在差异。肿瘤血管内皮细胞能动态的适应肿瘤微环境的变化,因此,在不同肿瘤,不同发展阶段,不同生长部位,同一条脉管不同区域,肿瘤血管内皮细胞均表现出异质性。了解肿瘤血管的异质性,不仅可以提高抗肿瘤血管生成药物的疗效,防止耐药性的产生,减少药物副反应,也为了解肿瘤组织中不同细胞间的相互作用打下基础。

Tumor angiogenesis is necessary for solid tumor progression and metastasis. Affected by the impact of tumor microenvironment. Tumor blood vessels have been shown to differ from normal counterparts, for example, by genotypic alterations, as well as the morphological and behavior changes. The ability of microvascular endothelial cells to respond dynamically to tumor-related microen- vironmental changes is particularly apparent in tumor-growth-associated angiogenesis. Heterogeneity of tumor vascular is brought about by variations in tumor cell dependency on the blood supply, the host environment in which the tumor grows, the tumor growth stage and so on. Understanding tumor endothelial cell abnormalities will help to develop ideal anti-angiogenic therapies and also to comprehend how tumor tissues are orchestrated by various cell types.