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microRNA影响抗肿瘤药物敏感性相关研究进展 被引量：2

Progression of anti-tumor drugs' sensitivity influenced by microRNA
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摘要 microRNA是一类长度为2l^25 nt非编码蛋白RNA,以干扰mRNA翻译的方式负向调控基因的表达。研究发现,microRNAs在肿瘤发生、发展过程中可能发挥癌基因或抑癌基因样作用,并表现为不同类型的肿瘤有其特异的microR-NA表达谱。多种microRNA与肿瘤发生、分化程度及预后等密切相关。随着microRNA家簇与肿瘤的联系逐渐被揭示,越来越多的证据表明肿瘤细胞对抗肿瘤药物的敏感性也受microRNA的影响。现对microRNA在影响抗肿瘤药物敏感性方面的一些研究做一综述。 MicroRNAs are 21-25 nucleotide （nt） non-coding RNA molecules that function as negatively post-transcriptional regulators of mRNA＇s translation. Researches have revealed that microRNA may act as an oncogene or anti-oncogene during the period of the occurrence and development of tumors, and showed that different tumors express its special microRNA expression profiles. Fur- thermore, many microRNAs are closely correlated to tumorigenesis, differentiation, prognosis and etc. As correlations between microR- NA cluster and tumors are being revealed, more and more evidences reveal that tumor＇s sensitivity to the anti-tumor drugs is influenced by microRNA. This paper will review some researches about the aspect of anti-tumor agents＇ sensitivity influenced by microRNA.
作者 陈勇 刘巍
机构地区 河北医科大学第四医院肿瘤内科
出处 《临床肿瘤学杂志》 CAS 2009年第9期860-863,共4页 Chinese Clinical Oncology
关键词 MICRORNA 耐药 抗肿瘤药物 MicroRNA Drug resistance Anti-tumor drug
分类号 R730 [医药卫生—肿瘤]
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参考文献24

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  • 9Sonkoly E, Bata-Csorgo Z, Pivarcsi AI. dentification and characterization of a novel, psoriasis susceptibility-related noncoding RNA gene, PRINS [ J]. J Biol Chem. 2005, 280:24159 -24167.
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临床肿瘤学杂志
2009年 第9期

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