脑囊虫病患者血清循环抗原、IgG4与神经影像学关系研究

Relationship of Serum Circulating Antigen and Specific IgG4 with Neuroimaging in Patients with Neurocysticercosis

目的探讨脑囊虫病血清循环抗原(CAg)、特异性IgG4与神经影像学(CT、MRI)的关系。方法对根据DelBrutto等于2001年提出的诊断脑囊虫病的四个标准确诊的36例脑囊虫病患者分别行CAg定量测定、IgG4定性测定及神经影像学检查。结果按照神经影像学变化,脑囊虫可分为活虫期、变性死亡早期、变性死亡后期及钙化期,其各期之间的患者血清CAg水平有显著差异(P<0.05)。血清中CAg的含量及血清特异性IgG4阳性强度与脑囊虫病的神经影像学分期呈显著正相关(r=0.871,0.602,P<0.01)。结论①脑囊虫病人血清CAg、IgG4水平与神经影像学(CT、MRI)表现具有相关性;②血清CAg和特异性IgG4的检查可用于脑囊虫病的早期诊断和指导其临床治疗。

Objective To investigate the relationship of serum circulating antigen （CAg） and specific IgG4 with neuroimaging in the patients with neurocystieereosis. Methods According to the four standards to diagnose neurocysticereosis which were introduced by Del Brutto et al in 2001, neurocysticercosis were definitely diagnosed as in 36 patients, in whom the quantitative assay of serum CAg, qualitative test of serum specific IgG4 and neuroimaging examination were performed. Results There were significantly differences in serum CAg and IgG4 contents among active stage, early degeneration stage, later degeneration stage, and calcic stage determined by the neuroimaging examination （P〈0.01）. The serum CAg content and the specific IgG4 intensity were significantly related with the stage of the neuroimaging of the neurocysticercosis （r=0.871 and 0.602 respectively, P〈0.01）. Conclusions （1） The serum CAg and IgG4 are related to the stage of the neuroimaging in the patients with neurocysticercosis. （2） Testing of serum CAg and specific IgG4 may be used for the early diagnosis and guiding the clinical treatment of the neurocysticercosis.